Applying Multiplex Strategies to Solve Multimodal Drug Discovery Problems

Time: 10:00 am
day: Day One

Details:

• Deploying our deep scanning mutagenesis approach to identify misfolded and mistrafficked variants that are amenable to small molecule chaperone therapy
• Multiplex assays at massive scale allow for comprehensive functional profiling of every possible missense mutation across a given target
• This Deep Mutational Scanning allows us to better address the genotype – phenotype problem, identify drug-responsive patient cohorts and map SARs from the target side