Cryo-EM in GPCR Structure-Based Drug Discovery

Time: 11:30 am
day: Day One


  • Cryo-EM is a valuable method adding to the repertoire of biophysical and structural techniques for GPCR structure based drug discovery
  • Exploitation of cryo-EM is now providing additional opportunities to solve structures of GPCRs for which limited tool ligands are available, which we will exemplify with cryo-EM enabled GPCR SBDD case studies
  • Cryo-EM has improved accessibility of challenging receptors to SBDD and has revealed novel modes of binding opening up new opportunities for modulating receptor function in disease