Discovery & Pharmacological Targeting of an Orphan GPCR with “AntiOpioid” Activity

Time: 4:00 pm
day: Day One


  • Unbiased forward genetic screening for regulators of opioid signaling using in vivo behavioral platform identifying GPR139 – a conserved orphan receptor antagonizing mu-opioid receptor actions
  • Biology of GPR139, its role in controlling function of brain circuits and animal behavior
  • Developing an assay to monitor GPR139 activity and performing HTS campaign to identify selective antagonists of GPR139